Heteroplasmy of mouse MtDNA is genetically unstable and results in altered behavior and cognition [J]
Contingent on promising early results, a major clinical trial (Phase 3) is conducted with hundreds to thousands of patients to confirm the treatments efficacy
This ensures we address health issues at their source
Clinical studies have confirmed that AOD-9604 does not stimulate IGF-1 production in any biological system tested, including human clinical trials monitoring serum IGF-1 levels over 24-week treatment periods
Even when consumed in large quantities, the potential for toxicity is low because the body does not retain most B12 that is consumed
Nature 551(7682):648652 Drannik A, Martin J, Peterson R, Ma X, Jiang F, Turnbull J (2017) Cerebrospinal fluid from patients with amyotrophic lateral sclerosis inhibits sonic hedgehog function