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It is involved in the viral attachment and in the host cell entry: the S1 subunit is able to bind the angiotensin-converting enzyme 2 (ACE2) receptor while, in a second step, the S2 subunit allows the virus to enter the cell by membrane fusion (122)

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Qiao L, Xu L, Yu L, Wynn J, Hernan R, Zhou X, et al

10.1093/jn/93.1.103 [DOI] [PubMed] [Google Scholar] Jung J

Currently, the modulation of intestinal microbiota through microecological therapies, including probiotics, prebiotics, and fecal microbiota transplantation, is a prominent area of clinical investigation for preventing and managing hyperuricemia and gout