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Our later studies on the Shank3 -/- and Cntnap2 -/- knockout mice, the human SH-SY5Y cell line, and the human induced pluripotent stem cellsderived cortical neurons isolated from patients carrying a SHANK3 mutation confirmed the increased levels of NO and protein SNO [172,173,174,175,176]

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Recent studies have demonstrated that mitochondrial iron overload in FRDA also activates ferroptosis, a regulated cell death pathway driven by iron-dependent lipid peroxidation, providing a mechanistic link between iron dyshomeostasis and neuronal loss [125]

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Association between glucose-lowering treatment and cancer metastasis among patients with preexisting type 2 diabetes and incident malignancy