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These drugs include: Anticoagulants including Coumadin (warfarin) and Plavix (clopidogrel) Oral corticosteroids including prednisone Other NSAIDs including aspirin, Aleve (naproxen), and Celebrex (celecoxib) Selective serotonin reuptake inhibitors including Prozac (fluoxetine) and Zoloft (sertraline) Serotonin-norepinephrine reuptake inhibitors including Effexor (venlafaxine) and Cymbalta (duloxetine) If you take alcohol and ibuprofen, and any of the above drugs, it can intensify all the substances effects