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Main exclusion criteria included recent gastrointestinal discomfort (e.g., abdominal pain or diarrhea) within the previous month, recent use of antibiotics, use of probiotics or prebiotics within the previous month, and advanced chronic kidney disease or other metabolic disorders (thyroid dysfunction, Cushing syndrome, acromegaly, and pheochromocytoma)

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Calcification causes blood vessels to harden and thicken, which means the heart has to work harder to pump blood around the body

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