The primary end point was the proportion of patients who met the psoriatic arthritis response criteria (PsARC), first developed for the PsA trials with sulfasalazine
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Simultaneously, the preservation of SAM levels maintains cellular capacity for critical methylation reactions including histone modifications, DNA methylation, and protein methylation that regulate gene expression and protein function
This means that there is no risk of overdosing when you get a vitamin B12 shot.
In that case, the process backs up, and homocysteine levels accumulate, putting additional strain on the methylation cycle to remove it
