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Nevertheless, no inhibitor has yet reached phase I clinical trials and further efforts are needed to circumvent all obstacles related to absorption, metabolism and various issues on pharmacokinetics in order to eventually achieve orally bioavailable drug candidates acting as cognitive enhancers in vivo

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L-Carnitine is the naturally occurring amino acid derivative essential for shuttling long-chain fatty acids into mitochondria for beta-oxidation and ATP production, as described in scientific literature ([ods.od.nih.gov]( The L-form is the only biologically active isomer D-carnitine is inactive and potentially inhibitory

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