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In tau transgenic mice we saw improvements in brain structure and function by reducing senescent cell burden by 30% with an intermittent treatment strategy (35), which is consistent with preclinical studies on other models of aging and/or disease (37, 45, 46, 101103, 108112)

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Allergic airway inflammation induces tachykinin peptides expression in vagal sensory neurons innervating mouse airways

[80] [81] [82] Other trials have confirmed reductions in symptoms, within 6 months in one trial, an effect that was maintained after withdrawal of the alpha blocker

As for adverse events, a similar percentage of participants across the treatment groups experienced the most common side effect of gastrointestinal upset [2]